Helse Sør-øst RHF
**PhD position**:
Offentlig forvaltning
Childhood cancer is a devastating disease and one of the leading causes of illness-related death in children in Norway. Tumors release molecular structures into body fluids such as blood, spinal fluid, and urine. These circulating particles, including cell-free DNA (cfDNA), extracellular vesicles (EVs), and metabolites, can be byproducts or molecular signals of the tumor, transmitting information between cells. In a process called liquid biopsy, they can be utilized to determine the status of the disease. Peripheral blood has traditionally been used in liquid biopsies; however, the volume is often limited. In contrast, urine-derived samples are less invasive, present in high abundance, and their composition can reflect dynamic physiological and pathological changes. In this project, we will analyze the composition and characteristics of cfDNA, isolate and characterize molecular cargo and targets of EVs, and profile the ...