Overview

The Nascimento Research Group is a newly established laboratory within the Department of Neuromuscular Diseases, focused on translational neuroscience and the study of spinal motor circuit neurophysiology in both animal models of disease, including ALS, and in human patients. The group uses a range of electrophysiological approaches in rodents alongside high-density surface electromyography (HDsEMG) in humans.

Responsibilities

• Study neuromuscular and spinal circuit pathophysiology in mouse models of Amyotrophic Lateral Sclerosis (ALS).
• Characterise the time‑course of alterations in spinal microcircuits, motoneurons, neuromuscular junctions, and muscle.
• Determine how these changes impact motor behaviour in mouse models of ALS.
• Employ neurophysiological recording techniques in mice, including in vitro motoneuron recordings from spinal cord preparations, in vivo motoneuron recordings from intact animals, and ex...