Dit ga je doen

The focus of this role is to establish and further develop cell models to study disease mechanisms and novel gene-targeted therapies for ALS.

ALS is a rapidly progressive, fatal disease in which motor neurons degenerate. Since 2024, for the first time in 150 years of research, effective gene-targeted therapies have become available for patients with specific mutations in the SOD1 gene (<1% of all ALS patients). In this research line, we develop in vitro patient models to investigate which patients may qualify for these and future gene-targeted therapies.

The laboratory technician will develop a diverse set of skills, including the transdifferentiation of fibroblasts and PBMCs into neurons (iNeurons), screening of antisense oligonucleotides (AONs), and characterization of treatment response through live-cell imaging, staining, and possibly electrophysiological studies or transcriptomic analyses. The infrastructure, expertise, and protoco...